A solution to the 2-pyridyl organometallic cross-coupling problem: regioselective catalytic direct arylation of pyridine N-oxides.
نویسندگان
چکیده
Direct arylation reactions of pyridine N-oxides occur in excellent yield with complete selectivity for the 2-position with a wide range of aryl bromides. This reactivity permits the use of inexpensive, commercially available, and bench-stable pyridine N-oxides as replacements for problematic 2-metallapyridines in palladium-catalyzed cross-coupling reactions.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 127 51 شماره
صفحات -
تاریخ انتشار 2005